HCID 89924447, Verbindung → 1226160-70-8

HRID 2200353Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2200353
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[CH2:10][C:9]1([CH3:22])[CH3:21])C1C=CC=CC=1>CO.C(OCC)(=O)C.[Pd]>[F:20][C:17]1[CH:16]=[CH:15][C:14]([N:11]2[CH2:12][CH2:13][NH:8][C:9]([CH3:22])([CH3:21])[CH2:10]2)=[CH:19][CH:18]=1

Komponenten

5

Edukt 1

HCID 89924447HCID 89924447, Verbindung

Produkt 1

HCID 572767191226160-70-8

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

To a stirred solution of 1-benzyl-4-(4-fluorophenyl)-2,2-dimethylpiperazine (4.5 g, 15.08 mmol) in methanol and ethyl acetate (5:1, 60 ml) at 25° C. was added 10% palladium on charcoal (1.605 g). The reaction mixture was stirred at 50° C. for 5 h. The progress of reaction was monitored by TLC. The reaction mixture was cooled to room temperature, filtered through a celite bed, washed with ethyl acetate (2×50 ml). The combined filtrate was concentrated under reduced pressure to obtain the title compound which was used in the next step without further purification.

Aufarbeitung

  1. customThe progress of reaction
  2. temperatureThe reaction mixture was cooled to room temperature
  3. filtrationfiltered through a celite bed
  4. washwashed with ethyl acetate (2×50 ml)
  5. concentrationThe combined filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-cddfff64cb2a4d51a3df076ec01decaa
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09359367B2

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