Sodium borohydride → (2-Methylpyrimidin-5-yl)methanol

HRID 2200559

Reaktionsgleichung

Reaktionsgleichung von HRID 2200559
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8](O)=[O:9])=[CH:4][N:3]=1.[BH4-].[Na+]>C(O)C>[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][N:3]=1

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 136708752-Methylpyrimidine-5-carboxylic acid

Produkt 1

HCID 14686706(2-Methylpyrimidin-5-yl)methanolAusbeute 70,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 2-methylpyrimidine-5-carboxylic acid (150 mg, 1.23 mm01) in ethanol (5 mL) was added sodium borohydride (93 mg, 2.46 mmol). The mixture was stirred at room temperature for 3 h. It was quenched with aqueous HCl (2 N, 2 mL), extracted with DCM, dried over sodium sulfate, filtered and concentrated give the yellow oil product (2-methylpyrimidin-5-yl)methanol (95 mg, 62.6%). LCMS MH+ 125.

Aufarbeitung

  1. customIt was quenched with aqueous HCl (2 N, 2 mL)
  2. extractionextracted with DCM
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-0e93240c86804c9f9b069ec1e3872045
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09359359B2

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