Dichloromethane → (1-Chloro-3-((4-methoxybenzyl)oxy)propan-2-yl)(trityl)sulfane

HRID 2201224Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2201224
[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:6]([CH2:7][O:8][CH2:9][CH:10]2[CH2:12][S:11]2)=[CH:5][CH:4]=1.[C:15](Cl)([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[Cl:35]CCl>>[Cl:35][CH2:12][CH:10]([S:11][C:15]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[CH2:9][O:8][CH2:7][C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:14][CH:13]=1

Komponenten

4

Edukt 3

HCID 6344DichloromethaneHCID 6456Trityl chlorideHCID 867234592-(((4-Methoxybenzyl)oxy)methyl)thiirane

Produkt 1

HCID 86723460(1-Chloro-3-((4-methoxybenzyl)oxy)propan-2-yl)(trityl)sulfane

Versuchsvorschrift

2-(((4-Methoxybenzyl)oxy)methyl)thiirane (496 mg, 2.359 mmol) was added to a solution of trityl chloride (598 mg, 2.144 mmol) in dichloromethane (10 mL). The mixture was stirred at room temperature for 16 hours, then evaporated under vacuum. Purification by chromatography on silica, eluting with 0-5% EtOAc/hexane, gave a crude material which was triturated with methanol to afford the title compound.

Aufarbeitung

  1. customevaporated under vacuum
  2. customPurification by chromatography on silica
  3. washeluting with 0-5% EtOAc/hexane
  4. customgave a crude material which
  5. customwas triturated with methanol

Quellen und Nachweise

ORD-Eintrag
ord-3134e65ea8b04e1faec6a6ae2f61234e
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09359381B2

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