Methanol → HCID 71061827, Verbindung

HRID 2201876Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2201876
C1(C([N:6]2[C:14]3[CH:13]=[C:12]([N:15]([C:21]([CH3:28])([CH2:23][C:24]([CH3:27])([CH3:26])[CH3:25])[CH3:22])[C:16]([CH:18]4[CH2:20][CH2:19]4)=[O:17])[N:11]=[CH:10][C:9]=3[CH:8]=[CH:7]2)=O)CC1.C(=O)([O-])[O-].[K+].[K+].CO>O>[NH:6]1[C:14]2[CH:13]=[C:12]([N:15]([C:21]([CH3:28])([CH2:23][C:24]([CH3:27])([CH3:26])[CH3:25])[CH3:22])[C:16]([CH:18]3[CH2:19][CH2:20]3)=[O:17])[N:11]=[CH:10][C:9]=2[CH:8]=[CH:7]1

Komponenten

5

Edukt 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 71061818N-[1-(cyclopropylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]-N-(2,4,4-trimethylpentan-2-yl)cyclopropanecarboxamide

Produkt 1

HCID 71061827HCID 71061827, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of N-[1-(cyclopropylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]-N-(2,4,4-trimethylpentan-2-yl)cyclopropanecarboxamide (65 mg, 0.16 mmol), potassium carbonate, methanol and water was stirred at room temperature for 20 minutes. Methanol was removed under vacuum. The residue was stirred in water for 30 minutes. The precipitated solid was filtered and dried to 47 mg (90%) N-(1H-pyrrolo[3,2-c]pyridin-6-yl)-N-(2,4,4-trimethylpentan-2-yl)cyclopropane carboxamide.

Aufarbeitung

  1. customMethanol was removed under vacuum
  2. stirringThe residue was stirred in water for 30 minutes
  3. filtrationThe precipitated solid was filtered
  4. dry with materialdried to 47 mg (90%) N-(1H-pyrrolo[3,2-c]pyridin-6-yl)-N-(2,4,4-trimethylpentan-2-yl)cyclopropane carboxamide

Quellen und Nachweise

ORD-Eintrag
ord-f1a34f51733a4efd8220f80631bf5308
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09364466B2

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