Lithium hydroxide, monohydrate → Lithium 1-(2-chloro-benzenesulfonyl)-piperidine-3-carboxylate

HRID 220206Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 220206
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][N:8]([S:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:21])(=[O:14])=[O:13])[CH2:7]1)=[O:5])C.O[Li:23].O>C1COCC1.CO.O>[Cl:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[S:12]([N:8]1[CH2:9][CH2:10][CH2:11][CH:6]([C:4]([O-:5])=[O:3])[CH2:7]1)(=[O:13])=[O:14].[Li+:23]

Komponenten

4

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 38620101-(2-Chloro-benzenesulfonyl)-piperidine-3-carboxylic acid ethyl ester

Produkt 1

HCID 67131265Lithium 1-(2-chloro-benzenesulfonyl)-piperidine-3-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21892291Methanol tetrahydrofuran waterLösungsmittel

Versuchsvorschrift

To a solution of 5.7 g 1-(2-chloro-benzenesulfonyl)-piperdine-3-carboxylic acid ethyl ester (17 mmol) in 30 mL THF: methanol: water (2:1:1) was added 1.08 g LiOH.H2O (25.7 mmol). The mixture was stirred at room temperature for 5-6 h and all volatiles were evaporated to dryness. The compound was used in the consecutive step without further purification.

Aufarbeitung

  1. customall volatiles were evaporated to dryness
  2. customThe compound was used in the consecutive step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-451a63a2c58144919bdae4ecfb673cf6
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08202888B2

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