Phenethyl bromide → HCID 10618874, Verbindung

HRID 2202152Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2202152
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[C:11]([CH:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[NH:10][N:9]=2)=[CH:4][CH:3]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>CN(C=O)C.CCOC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[C:11]([CH:13]3[CH2:18][CH2:17][N:16]([CH2:26][CH2:27][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[CH2:15][CH2:14]3)[NH:10][N:9]=2)=[CH:4][CH:3]=1

Komponenten

6

Edukt 3

HCID 7666Phenethyl bromideHCID 11430Potassium CarbonateHCID 4491264-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]piperidine2×

Produkt 1

HCID 10618874HCID 10618874, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 4-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]piperidine (INTERMEDIATE 7, 4 g, 15.28 mmol) in 60 mL DMF was added K2CO3 (63 g, 45.8 mmol), and 2-(bromoethyl)benzene (2.3 mL, 16.8 mmol). The reaction mixture was stirred at ambient temperature overnight, diluted with EtOAc, and washed three times with water. The organic layer was separated, dried (MgSO4), and concentrated under reduced pressure. LC-MS m/z=366.17 [M+1]+.

Aufarbeitung

  1. washwashed three times with water
  2. customThe organic layer was separated
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1611d3c8b3a147a3a4cc38eadca9dfc5
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09365539B2

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