Methylamine → 6-Chloro-N-methyl-1,3-benzothiazol-2-amine

HRID 2202371Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2202371
Cl[C:2]1[S:3][C:4]2[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:12][NH2:13]>C1COCC1.O>[Cl:11][C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[C:2]([NH:13][CH3:12])[S:3][C:4]=2[CH:10]=1

Komponenten

5

Edukt 2

HCID 6329MethylamineHCID 771762,6-Dichlorobenzothiazole

Produkt 1

HCID 107743586-Chloro-N-methyl-1,3-benzothiazol-2-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 2,6-dichlorobenzo[d]thiazole (2 g, 10 mmol) in 10 mL THF was added 25% MeNH2 in water (3 mL) dropwise. After the addition complete, the reaction mixture was stirred at room temperature overnight. Filter off the product and washed with methanol. Drying in vacuo to yield 1.5 g of the desired compound. LC-MS: m/z 204.2 (M+H)+

Aufarbeitung

  1. filtrationFilter off the product
  2. washwashed with methanol
  3. customDrying in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-fec4847eb50948bfa3139a0e452d3549
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09365545B2

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