Ethyl 2-(oxetan-3-ylidene)propanoate → Ethyl 2-(oxetan-3-yl)propanoate

HRID 2202570Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2202570
[O:1]1[CH2:4][C:3](=[C:5]([CH3:11])[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:2]1>CCO.[Pd]>[O:1]1[CH2:2][CH:3]([CH:5]([CH3:11])[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:4]1

Komponenten

4

Edukt 1

HCID 86698951Ethyl 2-(oxetan-3-ylidene)propanoate

Produkt 1

HCID 86698952Ethyl 2-(oxetan-3-yl)propanoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of (i) (151 mg, 0.97 mmol) in EtOH (54 mL) was added 10% Pd/C (50 mg, 0.05 mmol). The reaction was degassed and purged with hydrogen at balloon pressure (×3) then stirred under hydrogen at RT for 16 h. The reaction mixture was filtered and the residue washed with acetonitrile (10 mL). The combined organics were concentrated in vacuo and the residue, (ii) (148 mg), was used without further purification.

Aufarbeitung

  1. customThe reaction was degassed
  2. custompurged with hydrogen at balloon pressure (×3)
  3. filtrationThe reaction mixture was filtered
  4. washthe residue washed with acetonitrile (10 mL)
  5. concentrationThe combined organics were concentrated in vacuo
  6. customthe residue, (ii) (148 mg), was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-3c970b877a9b4bc5841d602b2bc04e07
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09365554B2

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