Chloroacetaldehyde → HCID 90427811, Verbindung
Reaktionsgleichung
[NH2:1][C:2]1[N:9]=[C:8]([CH3:10])[CH:7]=[C:6]([CH3:11])[C:3]=1[C:4]#[N:5].Cl[CH2:13][CH:14]=O>O>[CH3:10][C:8]1[N:9]2[CH:13]=[CH:14][N:1]=[C:2]2[C:3]([C:4]#[N:5])=[C:6]([CH3:11])[CH:7]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 80 °C
Versuchsvorschrift
To a stirred solution of compound 2-amino-4,6-dimethylnicotinonitrile (1 equiv.) in water was added chloroacetaldehyde (55% aq. solution) (1.2 equiv.) and reaction was heated at 80° C. for 16 h. On completion, it was quenched by 1N NaOH till pH 8. Solid precipitated was filtered and vacuum dried to afford the title compound (75% yield).
Aufarbeitung
- customOn completion, it was quenched by 1N NaOH till pH 8
- customSolid precipitated
- filtrationwas filtered
- customvacuum dried
Quellen und Nachweise
- ORD-Eintrag
- ord-bccb5f26f4754665b1009a4ec0532d0b
- Quelldatensatz
- uspto-grants-2016_06
- Patentnummer
- US09365570B2
Notizen zur Reaktion
Wird geladen…