4-Chloro-7-methoxy-6-nitroquinazoline → N4-(5-chlorobenzo[d][1,3]dioxol-4-yl)-7-methoxyquinazoline-4,6-diamine

HRID 2205313Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2205313
ClC1C=C(NC2C3C(=CC(OCCOC)=C(N)C=3)N=CN=2)C=CC=1F.Cl[C:27]1[C:36]2[C:31](=[CH:32][C:33]([O:40][CH3:41])=[C:34]([N+:37]([O-])=O)[CH:35]=2)[N:30]=[CH:29][N:28]=1.[Cl:42][C:43]1[CH:51]=[CH:50][C:46]2[O:47][CH2:48][O:49][C:45]=2[C:44]=1[NH2:52]>>[Cl:42][C:43]1[CH:51]=[CH:50][C:46]2[O:47][CH2:48][O:49][C:45]=2[C:44]=1[NH:52][C:27]1[C:36]2[C:31](=[CH:32][C:33]([O:40][CH3:41])=[C:34]([NH2:37])[CH:35]=2)[N:30]=[CH:29][N:28]=1

Komponenten

4

Edukt 3

HCID 104901874-Chloro-7-methoxy-6-nitroquinazolineHCID 113672535-Chloro-1,3-benzodioxol-4-amineHCID 18765584N4-(3-Chloro-4-fluorophenyl)-7-(2-methoxyethoxy)quinazoline-4,6-diamine

Produkt 1

HCID 86727278N4-(5-chlorobenzo[d][1,3]dioxol-4-yl)-7-methoxyquinazoline-4,6-diamine

Versuchsvorschrift

Starting material: N4-(5-chlorobenzo[d][1,3]dioxol-4-yl)-7-methoxyquinazoline-4,6-diamine was prepared according to the same method of preparation of N4-(3-chloro-4-fluorophenyl)-7-(2-methoxy)ethoxyquinazoline-4,6-diamine in WO2008/33747, but the starting material were 4-chloro-7-methoxy-6-nitroquinazoline and 5-chlorobenzo[d][1,3]dioxolan-4-amine; other starting materials were prepared as example 1.

Aufarbeitung

  1. customother starting materials were prepared as example 1

Quellen und Nachweise

ORD-Eintrag
ord-413ecd210be642cbbd61475a66a7d6ee
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09371292B2

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