1-(3-Methoxy-4-nitrophenyl)-N,N-dimethylmethanamine → 4-((Dimethylamino)methyl)-2-methoxyaniline
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:12][N:13]([CH3:15])[CH3:14])[CH:6]=[CH:7][C:8]=1[N+:9]([O-])=O>CCO.[Pd]>[CH3:15][N:13]([CH2:12][C:5]1[CH:6]=[CH:7][C:8]([NH2:9])=[C:3]([O:2][CH3:1])[CH:4]=1)[CH3:14]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
10% Pd on carbon (12 mg, 0.866 mmol) was added to a solution of 1-(3-methoxy-4-nitrophenyl)-N,N-dimethylmethanamine (Preparation 109, 160 mg, 0.76 mmol) in EtOH (3 mL). The reaction mixture was degassed and then stirred for 1 hour at room temperature under an atmosphere of hydrogen before being filtered on a pad of Celite and concentrated under reduced pressure to afford the title compound (0.135 g, 98%).
Aufarbeitung
- customThe reaction mixture was degassed
- filtrationbefore being filtered on a pad of Celite
- concentrationconcentrated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-517c8583a8f54bccb7f8733f5f1abf39
- Quelldatensatz
- uspto-grants-2016_06
- Patentnummer
- US09371319B2
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