Water → 3-iodo-4-methoxy-1-trityl-1H-pyrazolo[4,3-c]pyridine

HRID 2206258Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2206258
Cl[C:2]1[C:7]2[C:8]([I:30])=[N:9][N:10]([C:11]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:6]=2[CH:5]=[CH:4][N:3]=1.[CH3:31][OH:32].C[O-].[Na+].O>C1COCC1>[I:30][C:8]1[C:7]2[C:2]([O:32][CH3:31])=[N:3][CH:4]=[CH:5][C:6]=2[N:10]([C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:9]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 23694274Sodium methanolate methanolHCID 596190194-Chloro-3-iodo-1-trityl-1h-pyrazolo[4,3-c]pyridine

Produkt 1

HCID 668254573-iodo-4-methoxy-1-trityl-1H-pyrazolo[4,3-c]pyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

To a solution of 4-chloro-3-iodo-1-trityl-1H-pyrazolo[4,3-c]pyridine (1.7 g) in THF (20 mL) was added sodium methoxide methanol solution (1.5 M, 2.7 mL) at room temperature, and the mixture was stirred at 50° C. for 2 hr. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the title compound (1.6 g).

Aufarbeitung

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-52bd61facf5d4455aef999868947a82c
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09371320B2

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