tert-Butyl {2-nitro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate → tert-butyl N-{2-amino-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

HRID 220634

Reaktionsgleichung

Reaktionsgleichung von HRID 220634
[N+:1]([CH2:4][CH:5]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=1)([O-])=O>CO.[Pd]>[NH2:1][CH2:4][CH:5]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:21])([CH3:20])[CH3:22])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=1

Komponenten

4

Edukt 1

HCID 59536870tert-Butyl {2-nitro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

Produkt 1

HCID 43094068tert-butyl N-{2-amino-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Of the compound from Example 12A, 248 mg (1.04 mmol) were introduced in methanol and admixed with 20 mg of palladium (10% on activated carbon). Hydrogenation took place under atmospheric pressure at RT overnight. The reaction mixture was filtered and the filtrate concentrated under reduced pressure. This gave 300 mg (88% of theory) of the title compound.

Aufarbeitung

  1. customat RT
  2. customovernight
  3. filtrationThe reaction mixture was filtered
  4. concentrationthe filtrate concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b0a917e00b6b47628c2c54093e81da98
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08202895B2

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