Formic Acid → tert-Butyl [(2-chlorophenyl)(phenylsulphonyl)methyl]carbamate

HRID 220656

Reaktionsgleichung

Reaktionsgleichung von HRID 220656
[C:1](=[O:8])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])[NH2:2].[Na+].[C:10]1([S:16]([O-:18])=[O:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[Cl:19][C:20]1[CH:27]=[CH:26][CH:25]=[CH:24][C:21]=1[CH:22]=O.C(O)=O>CO.O>[Cl:19][C:20]1[CH:27]=[CH:26][CH:25]=[CH:24][C:21]=1[CH:22]([NH:2][C:1](=[O:8])[O:3][C:4]([CH3:7])([CH3:6])[CH3:5])[S:16]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:18])=[O:17]

Komponenten

6

Edukt 4

HCID 284Formic AcidHCID 69962-ChlorobenzaldehydeHCID 77922tert-Butyl carbamateHCID 2723840Benzenesulfinic acid, sodium salt

Produkt 1

HCID 59536806tert-Butyl [(2-chlorophenyl)(phenylsulphonyl)methyl]carbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 22242641Methanol--water (1/1)Lösungsmittel

Versuchsvorschrift

Quantities of 2.78 g (23.7 mmol) of tert-butyl carbamate and 7.79 g (47.4 mmol) of benzenesulphinic acid sodium salt were introduced in 55 ml of methanol/water 1:2 at RT and admixed with 5 g (35.6 mmol) of 2-chlorobenzaldehyde and then with 1.78 ml (47.1 mmol) of formic acid. The mixture was stirred at RT for 2 days. The white solid precipitated was filtered off with suction and washed in succession twice each with water and diethyl ether. Drying in an HV gave 5.77 g (42% of theory) of the title compound.

Aufarbeitung

  1. customThe white solid precipitated
  2. filtrationwas filtered off with suction
  3. washwashed in succession twice each with water and diethyl ether
  4. customDrying in an HV

Quellen und Nachweise

ORD-Eintrag
ord-e17fb02282f34901aeb55b4f32a4045b
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08202895B2

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