Ammonium Chloride → (S)-2-(4-isobutyl-phenyl)-propionic acid 2-(3,5-dichloro-pyridin-4-yl)-1-(3,4-dimethoxy-phenyl)-ethyl ester

HRID 220715

Reaktionsgleichung

Reaktionsgleichung von HRID 220715
Cl.C(N=C=NCCCN(C)C)C.[Cl:13][C:14]1[CH:15]=[N:16][CH:17]=[C:18]([Cl:33])[C:19]=1[CH2:20][CH:21]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH3:32])[CH:24]=1)[OH:22].[CH2:34]([C:38]1[CH:43]=[CH:42][C:41]([C@H:44]([CH3:48])[C:45](O)=[O:46])=[CH:40][CH:39]=1)[CH:35]([CH3:37])[CH3:36].[NH4+].[Cl-]>CN(C)C1C=CN=CC=1.C(Cl)Cl>[Cl:33][C:18]1[CH:17]=[N:16][CH:15]=[C:14]([Cl:13])[C:19]=1[CH2:20][CH:21]([O:22][C:45](=[O:46])[C@H:44]([C:41]1[CH:42]=[CH:43][C:38]([CH2:34][CH:35]([CH3:37])[CH3:36])=[CH:39][CH:40]=1)[CH3:48])[C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH3:32])[CH:24]=1

Komponenten

7

Edukt 4

HCID 25517Ammonium ChlorideHCID 39912DexibuprofenHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride2×HCID 670959732-(3,5-Dichloropyridin-4-yl)-1-(3,4-dimethoxyphenyl)ethanol

Produkt 1

HCID 67096033(S)-2-(4-isobutyl-phenyl)-propionic acid 2-(3,5-dichloro-pyridin-4-yl)-1-(3,4-dimethoxy-phenyl)-ethyl esterAusbeute 82,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

(1-Ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride) (EDC.HCl) (345 mg, 3 eq.) is added to a solution of 2-(3,5-dichloro-pyridin-4-yl)-1-(3,4-dimethoxy-phenyl)-ethanol (200 mg, 1 eq.), (S)-2-(4-isobutyl-phenyl)-propionic acid (148 mg, 1.2 eq.) and 4-dimethylaminopyridine (DMAP) (37 mg, 0.5 eq.) in dry CH2Cl2 (8 mL) at room temperature under nitrogen atmosphere. The mixture is stirred at room temperature overnight, then it is treated with a saturated solution of NH4Cl (20 ml) and extracted with EtOAc (2×20 ml). The combined organic layer are dried over Na2SO4 and the solvent is evaporated. The crude is purified by flash chromatography on silica gel in gradient elution (from petroleum ether/EtOAc 9/1 v/v to petroleum ether/EtOAc 7/3 v/v) to yield 259 mg of pure compound.

Aufarbeitung

  1. extractionextracted with EtOAc (2×20 ml)
  2. dry with materialThe combined organic layer are dried over Na2SO4
  3. customthe solvent is evaporated
  4. customThe crude is purified by flash chromatography on silica gel in gradient elution (from petroleum ether/EtOAc 9/1 v/v to petroleum ether/EtOAc 7/3 v/v)

Quellen und Nachweise

ORD-Eintrag
ord-fe0af1d35e0d44a29c487f37c1987e1a
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08203000B2

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