o-Xylyl bromide → 2-[[3-Acetyl-1-(o-tolylmethyl)pyridin-1-ium-4-yl]methyl]-6-methoxy-tetralin-1-one bromide
Reaktionsgleichung
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2].[CH3:24][C:25]1[CH:32]=[CH:31][CH:30]=[CH:29][C:26]=1[CH2:27][Br:28]>>[Br-:28].[C:1]([C:4]1[CH:5]=[N+:6]([CH2:24][C:25]2[CH:32]=[CH:31][CH:30]=[CH:29][C:26]=2[CH3:27])[CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2]Komponenten
3
Versuchsvorschrift
The title compound 121 is prepared according to the procedure reported in Example 38.1 with compound 103 (62 mg, 0.2 mmol) and 2-methylbenzyl bromide (45 μL, 0.34 mmol) as reactants. White solid. (Yield 73.9 mg, 75%).
Quellen und Nachweise
- ORD-Eintrag
- ord-a97f40be23894d51b9dd2d62a8a15c3b
- Quelldatensatz
- uspto-grants-2016_06