Hydrochloric Acid → 2-Pyrrolidinecarboxamide, 4-fluoro-, hydrochloride (1:1), (2S,4S)-

HRID 220744Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 220744
[F:1][C@@H:2]1[CH2:6][NH:5][C@H:4]([C:7]([NH2:9])=[O:8])[CH2:3]1.[ClH:10]>C(O)(C)C.CCOCC>[ClH:10].[F:1][C@@H:2]1[CH2:6][NH:5][C@H:4]([C:7]([NH2:9])=[O:8])[CH2:3]1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 12066286(2S,4S)-4-Fluoropyrrolidine-2-carboxamide

Produkt 1

HCID 451589172-Pyrrolidinecarboxamide, 4-fluoro-, hydrochloride (1:1), (2S,4S)-Ausbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

(2S,4S)-4-Fluoropyrrolidine-2-carboxamide (119 mg, 0.9 mmol) obtained in step 1 was dissolved in 5 ml of isopropanol. Into the solution, 1.5 mL (HCl 1.5 mmol) of 1.0 M HCl in ether was added, and after the mixture was stirred for 10 minutes, all the volatiles were removed. The resulting solid was dried in vacuum at 50° C. for 2 h, giving 148 mg (yield 98%) of (2S,4S)-4-fluoropyrrolidine-2-carboxamide hydrochloride (Ga). The product was identified by comparison with an authentic sample.

Aufarbeitung

  1. customall the volatiles were removed
  2. customThe resulting solid was dried in vacuum at 50° C. for 2 h

Quellen und Nachweise

ORD-Eintrag
ord-88abaa587d6843d2821d7429a2ca88be
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08203003B2

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