Malonic Acid → HCID 54545488, Verbindung

HRID 2207897Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2207897
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH:8]=O)[CH:3]=1.C(O)(=O)[CH2:11][C:12]([OH:14])=[O:13].N1CCCCC1>N1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH:8]=[CH:11][C:12]([OH:14])=[O:13])[CH:3]=1

Komponenten

5

Edukt 3

HCID 867Malonic AcidHCID 8082PiperidineHCID 147614724-Bromopyridine-2-carbaldehyde

Produkt 1

HCID 54545488HCID 54545488, VerbindungAusbeute 51,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

4-Bromo-pyridin-2-carbaldehyde (10.0 g, 53.5 mmol), malonic acid (12.5 g, 120.5 mmol), and piperidine (4.4 mL, 44.4 mmol) were added to pyridine (32.5 mL). The reaction mixture was stirred at 100° C. for 1 hour, concentrated under reduced pressure, and then distilled water was added thereto. The mixture was filtered and then the resulting solid was dried under reduced pressure to give 6.3 g of the titled compound as a white solid.

Aufarbeitung

  1. concentrationconcentrated under reduced pressure
  2. additiondistilled water was added
  3. filtrationThe mixture was filtered
  4. customthe resulting solid was dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-091fc3bf3e084bee88f4371705bbfb63
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09376420B2

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