Benzoyl chloride → HCID 57555405, Verbindung

HRID 220811

Reaktionsgleichung

Reaktionsgleichung von HRID 220811
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[OH:9].C(=O)(O)[O-].[Na+].[C:15](Cl)(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CCOC(C)=O.O>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:15](=[O:22])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:3]([OH:9])[CH:4]=1

Komponenten

6

Edukt 3

HCID 7412Benzoyl chlorideHCID 915912-Amino-5-chlorophenolHCID 516892Sodium Bicarbonate

Produkt 1

HCID 57555405HCID 57555405, VerbindungAusbeute 82,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

2-Amino-5-chlorophenol (1.45 g, 10 mmol) was dissolved in EtOAc (30 ml) and water (20 ml). Sodium bicarbonate (1.25 g, 15 mmol) then benzoyl chloride (1.42 g, 10 mmol) were added and the mixture was stirred at room temperature for 1 h. The layers were partitioned and the organic layer was washed with brine, dried and concentrated in vacuo. The residue was triturated with di-ethyl ether to yield the title compound (2.05 g, 82%).

Aufarbeitung

  1. customThe layers were partitioned
  2. washthe organic layer was washed with brine
  3. customdried
  4. concentrationconcentrated in vacuo
  5. customThe residue was triturated with di-ethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-10d36463adb94f57853f5b42f12f0bdb
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08202858B2

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