Morpholine → Morpholine, 4-(2-methoxyethyl)-

HRID 2209329Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2209329
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH3:7][O:8][CH2:9][CH2:10]Cl>>[CH3:7][O:8][CH2:9][CH2:10][N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 8083MorpholineHCID 123162-Chloroethyl methyl ether

Produkt 1

HCID 82460Morpholine, 4-(2-methoxyethyl)-

Versuchsvorschrift

In an autoclave of 100 mL, morpholine (45.0 g, 517 mmol) was made reacted with chloroethyl methyl ether (25.0 g, 265 mmol) at 130 deg C. for 48 hours. Solid salt that was formed was removed by filtration, and residue (filtrate) was subjected to reduced-pressure distillation by using a Vigreux column of 25 cm. Then 1H-NMR measurement of obtained amine is performed, and it was confirmed that chemical shifts, δ (ppm), are 3.53-3.55(m, 4H), 3.33-3.35(m, 2H), 3.17(s, 3H), and 2.36-2.32 (m, 6H), and that N-2-methoxyethylmorpholine was synthesized.

Aufarbeitung

  1. customSolid salt that was formed
  2. customwas removed by filtration, and residue (filtrate)
  3. distillationwas subjected to reduced-pressure distillation

Quellen und Nachweise

ORD-Eintrag
ord-569b4e245c044095ae2153b5d5a9beb1
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09379413B2

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