Morpholine → 173158-11-7

HRID 2210470Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2210470
[C:1]([C:4]1[CH:5]=[C:6]([S:10](F)(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>C1COCC1>[C:1]([C:4]1[CH:5]=[C:6]([S:10]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 8083MorpholineHCID 128213-Acetylbenzenesulfonyl fluoride

Produkt 1

HCID 962213173158-11-7

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 20.02 g (0.1 mol) of 3-acetylbenzenesulfonyl fluoride and 29 ml of morpholine in 100 mL of THF is stirred at room temperature for 16 hours. The solvent is removed, the residue dissolved in CH2C2, and solution washed with H20 and 2N HCl. The organic layer is dried (MgSO4), the solvent removed, and the residue crystallized from CH2Cl2 -hexane to give 25.2 g (93%) of light yellow crystals, m.p. 144°-147° C.

Aufarbeitung

  1. customThe solvent is removed
  2. dissolutionthe residue dissolved in CH2C2, and solution
  3. washwashed with H20 and 2N HCl
  4. dry with materialThe organic layer is dried (MgSO4)
  5. customthe solvent removed
  6. customthe residue crystallized from CH2Cl2 -hexane
  7. customto give 25.2 g (93%) of light yellow crystals, m.p. 144°-147° C.

Quellen und Nachweise

ORD-Eintrag
ord-c2644188701d44138328be6033010647
Quelldatensatz
uspto-grants-1995_10
Patentnummer
US05459131

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