Water → Methyl 2,3-dihydro-4-methyl-2-thioxothieno[3,4-d]imidazole-6-carboxylate

HRID 2211287

Reaktionsgleichung

Reaktionsgleichung von HRID 2211287
[NH2:1][C:2]1[C:6]([NH2:7])=[C:5]([C:8]([O:10][CH3:11])=[O:9])[S:4][C:3]=1[CH3:12].C1N=CN([C:18](N2C=NC=C2)=[S:19])C=1.O>CN(C=O)C>[CH3:12][C:3]1[S:4][C:5]([C:8]([O:10][CH3:11])=[O:9])=[C:6]2[C:2]=1[NH:1][C:18](=[S:19])[NH:7]2

Komponenten

5

Edukt 3

HCID 962WaterHCID 802641,1'-ThiocarbonyldiimidazoleHCID 18693138Methyl 3,4-diamino-5-methylthiophene-2-carboxylate

Produkt 1

HCID 19376767Methyl 2,3-dihydro-4-methyl-2-thioxothieno[3,4-d]imidazole-6-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

A mixture of methyl 3,4-diamino-2-methylthiophene-5-carboxylate (1.0 g) and N,N'-thiocarbonyldiimidazole (1.1 g) in DMF (5 ml) was stirred at 50° C. for one hour. To the reaction mixture was added water to give crystals. Recrystallization from DMF-water afforded colorless prisms (1.2 g, quantitatively), m.p. 285°-288° C. (dec.)

Aufarbeitung

  1. customto give crystals
  2. customRecrystallization from DMF-water afforded colorless prisms (1.2 g

Quellen und Nachweise

ORD-Eintrag
ord-6367b16a79fe4ff8a330aff245e33d58
Quelldatensatz
uspto-grants-1995_10
Patentnummer
US05463073

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