Triethylamine → Methanesulfonic acid 3-benzenesulfonyl-3-methylbutyl ester

HRID 2212070Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2212070
[C:1]1([S:7]([C:10]([CH3:15])([CH3:14])[CH2:11][CH2:12][OH:13])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[CH3:23][S:24](Cl)(=[O:26])=[O:25]>>[C:1]1([S:7]([C:10]([CH3:15])([CH3:14])[CH2:11][CH2:12][O:13][S:24]([CH3:23])(=[O:26])=[O:25])(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

4

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 149069793-Benzenesulfonyl-3-methyl-butan-1-ol

Produkt 1

HCID 86595010Methanesulfonic acid 3-benzenesulfonyl-3-methylbutyl esterAusbeute 103,1 %

Versuchsvorschrift

A solution of 3-benzenesulfonyl-3-methyl-butan-1-ol (2.17 g, 9.5 mmol), triethylamine (2.0 ml, 14.25 mmol), methanesulphonyl chloride (0.9 ml, 11.78 mmol) and 4-N,N-dimethylaminopyridine (12 mg, 0.01 mmol) was stirred at 0° C. for 45 min. After quenching with satd. NaHCO3, the mixture was extracted into dichloromethane. The combined organic extracts were dried (Na2SO4) and concentrated to give the title product (3.0 g).

Aufarbeitung

  1. customAfter quenching with satd
  2. extractionNaHCO3, the mixture was extracted into dichloromethane
  3. dry with materialThe combined organic extracts were dried (Na2SO4)
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-4f69f1bcb9d44b4b9564223aaaf7654c
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07101892B2

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