3-(4-Benzyloxy-phenyl)-3-hydroxy-2-methyl-propionic acid methyl ester → 3-Hydroxy-3-(4-hydroxy-phenyl)-2-methyl-propionic acid methyl ester

HRID 2212565Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2212565
[CH3:1][O:2][C:3](=[O:22])[CH:4]([CH3:21])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([O:13]CC2C=CC=CC=2)=[CH:9][CH:8]=1)[OH:6].[H][H]>CO.[Pd]>[CH3:1][O:2][C:3](=[O:22])[CH:4]([CH3:21])[CH:5]([OH:6])[C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1

Komponenten

5

Edukt 2

HCID 695964413-(4-Benzyloxy-phenyl)-3-hydroxy-2-methyl-propionic acid methyl esterHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 623934773-Hydroxy-3-(4-hydroxy-phenyl)-2-methyl-propionic acid methyl esterAusbeute 104,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

10% Pd/C was added to a degassed solution of 3-(4-benzyloxy-phenyl)-3-hydroxy-2-methyl-propionic acid methyl ester (0.335 g, 1.1 mmol) in methanol (30 mL) and charged to 50 PSI hydrogen, then shaken for 2.5 h. The reaction was filtered to remove the catalyst and concentrated to give 3-hydroxy-3-(4-hydroxy-phenyl)-2-methyl-propionic acid methyl ester (0.242 g, 100%) as an oil. MS found: (M+H)+=211.

Aufarbeitung

  1. filtrationThe reaction was filtered
  2. customto remove the catalyst
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-91687b1e531340e6bd403277c77ffb25
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07102008B2

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