Benzaldehyde → 7-Benzylidene-6,7-dihydro-5H-[1]pyrindine

HRID 2212814

Reaktionsgleichung

Reaktionsgleichung von HRID 2212814
[N:1]1[C:9]2[CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH:10](=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(OC(=O)C)(=O)C>>[CH:10](=[C:8]1[C:9]2[N:1]=[CH:2][CH:3]=[CH:4][C:5]=2[CH2:6][CH2:7]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Komponenten

4

Edukt 3

HCID 240BenzaldehydeHCID 7918Acetic AnhydrideHCID 68292Pyrindan

Produkt 1

HCID 674163677-Benzylidene-6,7-dihydro-5H-[1]pyrindineAusbeute 75 %

Versuchsvorschrift

15 g (0.125 mol) of 6,7-dihydro-5H-[1]pyrindine, 20.1 g (0.19 mol) of freshly destilled benzaldehyde and 24.5 g (0.24 mol) of acetic acid anhydride were heated under reflux for 24 h. The reaction mixture was evaporated, the residual oil dissolved in methylene chloride, the solution extracted with 1N NaOH solution, and the organic phase dried and evaporated. The residue was destilled under reduced pressure to give 19.3 g (75%) of the title compound.

Aufarbeitung

  1. temperatureunder reflux for 24 h
  2. customThe reaction mixture was evaporated
  3. dissolutionthe residual oil dissolved in methylene chloride
  4. extractionthe solution extracted with 1N NaOH solution
  5. customthe organic phase dried
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-b4246cd9d8eb40b4b6de6d466dbf1014
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07105513B2

Verknüpfte Notizen

Wird geladen…