Water → tert-Butyl [4-(1H-benzimidazol-2-yl)-1,3-thiazol-2-yl]methyl-carbamate

HRID 2213151

Reaktionsgleichung

Reaktionsgleichung von HRID 2213151
O(C)[Na].[C:4]([C:6]1[N:7]=[C:8]([CH2:11][NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])[S:9][CH:10]=1)#[N:5].Cl.Cl.[C:22]1(N)[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[NH2:28].O>CO>[NH:5]1[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[N:28]=[C:4]1[C:6]1[N:7]=[C:8]([CH2:11][NH:12][C:13](=[O:19])[O:14][C:15]([CH3:16])([CH3:18])[CH3:17])[S:9][CH:10]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 119901,2-Phenylenediamine dihydrochlorideHCID 22560011Tert-butyl ((4-cyanothiazol-2-YL)methyl)carbamateHCID 178418582HCID 178418582, Verbindung

Produkt 1

HCID 86760240tert-Butyl [4-(1H-benzimidazol-2-yl)-1,3-thiazol-2-yl]methyl-carbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

In analogy to the preparation of 8, 1.89 g of a 30% NaOCH3 solution were added to tert-butyl (4-cyano-1,3-thiazol-2-yl)methylcarbamate (2.5 g; 10.45 mmol) in 25 ml of CH3OH, and the mixture was stirred at room temperature for 2 h. Addition of 1.9 g of 1,2-phenylenediamine bishydrochloride was followed by stirring overnight, and then the reaction mixture was added to 100 ml of H2O, and the solid resulting after filtration was dried in vacuo.

Aufarbeitung

  1. stirringby stirring overnight
  2. customthe solid resulting
  3. filtrationafter filtration
  4. customwas dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f5ebaded0d65491ca59edccccd7fba4b
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07105508B1

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