Triethylamine → 2-Chloro-6-(4-chlorobenzylamino)purine

HRID 2215650Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2215650
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.C(N(CC)CC)C.[Cl:19][C:20]1[CH:27]=[CH:26][C:23]([CH2:24][NH2:25])=[CH:22][CH:21]=1>C(O)C>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([NH:25][CH2:24][C:23]2[CH:26]=[CH:27][C:20]([Cl:19])=[CH:21][CH:22]=2)[N:3]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 660364-ChlorobenzylamineHCID 53244122,6-Dichloropurine

Produkt 1

HCID 219518362-Chloro-6-(4-chlorobenzylamino)purine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a suspension of 15 g (0.0794 mol) of 2,6-dichloropurine in 250 mL of absolute ethanol was added 12.7 mL (0.0873 mol) of triethylamine and 10.62 mL (0.0873 mol) of 4-chlorobenzylamine. The mixture was refluxed at 80° C. for 16 h (the formation of creamy white precipitate was observed). The reaction mixture was cooled and the precipitated product was removed by filtration. The precipitate was washed with ethanol (350 mL) and dried in high vacuum for 24 h. Product was characterized by 1H-NMR.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. customthe precipitated product was removed by filtration
  3. washThe precipitate was washed with ethanol (350 mL)
  4. customdried in high vacuum for 24 h

Quellen und Nachweise

ORD-Eintrag
ord-925ebb556e1b4c25803035cfbabc0183
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07109330B2

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