Lithium Hydroxide → 4-[3-methyl-2-[3-[5-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]-2-methylsulfanylthiophen-3-yl]sulfonylphenyl]anilino]-4-oxobutanoic acid

HRID 2216049Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2216049
C([O:3][C:4](=[O:43])[CH2:5][CH2:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[C:11]=1[C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([S:23]([C:26]2[CH:30]=[C:29]([C:31]([NH:33][C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])=[NH:32])[S:28][C:27]=2[S:41][CH3:42])(=[O:25])=[O:24])[CH:18]=1)=[O:8])C.[Li+].[OH-]>CO>[C:37]([O:36][C:34]([NH:33][C:31](=[NH:32])[C:29]1[S:28][C:27]([S:41][CH3:42])=[C:26]([S:23]([C:19]2[CH:18]=[C:17]([C:11]3[C:12]([CH3:16])=[CH:13][CH:14]=[CH:15][C:10]=3[NH:9][C:7](=[O:8])[CH2:6][CH2:5][C:4]([OH:43])=[O:3])[CH:22]=[CH:21][CH:20]=2)(=[O:25])=[O:24])[CH:30]=1)=[O:35])([CH3:40])([CH3:38])[CH3:39]

Komponenten

4

Edukt 2

HCID 3939Lithium HydroxideHCID 145857693ethyl 4-[3-methyl-2-[3-[5-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]-2-methylsulfanylthiophen-3-yl]sulfonylphenyl]anilino]-4-oxobutanoate

Produkt 1

HCID 1458576434-[3-methyl-2-[3-[5-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]-2-methylsulfanylthiophen-3-yl]sulfonylphenyl]anilino]-4-oxobutanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

N-{3′-[5-(tert-Butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-biphenyl-2-yl}-succinamic acid ethyl ester (Example 133: step a) and LiOH were dissolved into MeOH and stirred at RT for 2 hours. The solvents were removed in vacuo yielding the title compound that was used with out further purification or characterization.

Aufarbeitung

  1. customThe solvents were removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6a650e17ea5140919c903a96619a889c
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07109354B2

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