1-Methylpiperazine → 5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile

HRID 2216391

Reaktionsgleichung

Cl[C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[CH:6][C:3]=1[C:4]#[N:5].[CH3:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>>[NH2:10][C:7]1[CH:8]=[CH:9][C:2]([N:17]2[CH2:18][CH2:19][N:14]([CH3:13])[CH2:15][CH2:16]2)=[C:3]([CH:6]=1)[C:4]#[N:5]

Komponenten

Edukt 2

HCID 531671-Methylpiperazine

HCID 855042-Chloro-5-nitrobenzonitrile

Produkt 1

HCID 176095815-Amino-2-(4-methylpiperazin-1-yl)benzonitrileAusbeute 62,5 %

Versuchsvorschrift

By the reaction and treatment in the same manner as in Starting Material Synthetic Example 4 using 2-chloro-5-nitrobenzonitrile (15 g) and methylpiperazine (9.8 g), the title compound (11.1 g) was obtained. melting point: 45-46° C.

Aufarbeitung

customBy the reaction and treatment in the same manner as

Quellen und Nachweise

ORD-Eintrag: ord-58fcb8b3c4f747289de79d546576b89c
Quelldatensatz: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07112594B2

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