HCID 21941479, Verbindung → 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carbaldehyde

HRID 2216629Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2216629
[NH:1]1[N:9]2[CH:4]([O:5][CH2:6][CH:7]=[CH:8]2)[CH2:3][CH:2]1[CH2:10][OH:11]>CCl.O=[Mn]=O>[N:1]1[N:9]2[C:4]([O:5][CH2:6][CH2:7][CH2:8]2)=[CH:3][C:2]=1[CH:10]=[O:11]

Komponenten

4

Edukt 1

HCID 21941479HCID 21941479, Verbindung

Produkt 1

HCID 118471296,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carbaldehydeAusbeute 104,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14801Manganese dioxideKatalysatorHCID 6327Methyl ChlorideLösungsmittel

Versuchsvorschrift

To the stirred solution of 2,3-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-2-yl-methanol (2.08 g, 13.5 mmol) in 60 ml of CH3Cl was added 9.38 g of MnO2. Th suspension was refluxed for 2 hour under a nitrogen atmosphere. The reaction mixture was filtered through a pad of Celite. The filtrate was concentrated to give yellow oil. The product was purified by chromatography. 2.15 g of the product was obtained (78%).

Aufarbeitung

  1. temperatureTh suspension was refluxed for 2 hour under a nitrogen atmosphere
  2. filtrationThe reaction mixture was filtered through a pad of Celite
  3. concentrationThe filtrate was concentrated
  4. customto give yellow oil
  5. customThe product was purified by chromatography

Quellen und Nachweise

ORD-Eintrag
ord-214b4e44f4c2445a8465de1088fd1b35
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07112582B2

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