Hydrochloric Acid → HCID 19927436, Verbindung

Reaktionsgleichung

O[CH:2]1[C:11]2[C:6](=[C:7]([OH:12])[CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[O:3]1.[C-:13]#[N:14].[K+].Cl.[OH2:17]>>[OH:12][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[C:4](=[O:5])[O:3][CH:2]2[C:13]([NH2:14])=[O:17]

Komponenten

Edukt 4

HCID 313Hydrochloric Acid

HCID 962Water

HCID 9032Potassium Cyanide

HCID 16748834HCID 16748834, Verbindung

Produkt 1

HCID 19927436HCID 19927436, Verbindung

Versuchsvorschrift

2.8 g of 3,7-dihydroxy-phthalide (see Examples 105 and 106) are introduced into a solution of 7.5 g of potassium cyanide in 35 ml of water, and 25 ml of concentrated hydrochloric acid are slowly added to the mixture while cooling with ice, so that the internal temperature does not exceed 10° C. The reaction mixture is maintained at room temperature for a further 5 hours and then the crystals are filtered off. Having been washed with water and dried well, the product (m.p. 213°-215° C.) is pure 4-hydroxy-1,3-dihydro-3-oxo-1-isobenzofurancarboxamide.