Acetic Acid → Quinoline-4-carbaldehyde methyl(phenyl)hydrazone

HRID 2217944

Reaktionsgleichung

Reaktionsgleichung von HRID 2217944
[CH3:1][N:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[NH2:3].C(O)(=O)C.[CH:14]([C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:19]=[CH:18][CH:17]=1)=O>C(O)C>[CH3:1][N:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[N:3]=[CH:14][C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:19]=[CH:18][CH:17]=1

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 36299N-methyl-N-phenyl-hydrazine2×HCID 780724-Quinolinecarboxaldehyde2×

Produkt 1

HCID 364169Quinoline-4-carbaldehyde methyl(phenyl)hydrazone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

One equivalent of methylphenylhydrazine (4.1 g; 0.033 mol, compound 2 was diluted in 25 ml of ethanol and 0.5 ml of glacial acetic acid in a three-necked flask on which was mounted a condenser. The reaction medium was then stirred at 0° C. 1 equivalent of 4-formylquinoline (5.28 g; 0.033 mol, compound 14) was added by spatula. After adding the aldehyde, the reaction medium was heated at 70° C. (oil bath temperature) for 4 hours.

Aufarbeitung

  1. temperaturethe reaction medium was heated at 70° C. (oil bath temperature) for 4 hours

Quellen und Nachweise

ORD-Eintrag
ord-0d071e769ecd4e128c39b2f5485a2956
Quelldatensatz
uspto-grants-2008_08
Patentnummer
US07410506B2

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