6-Nitro-5-methyl-2-ethoxy-3,1-benzoxazin-4-one → 6-Amino-5-methyl-2-ethoxy-3,1-benzoxazin-4-one

HRID 22183

Reaktionsgleichung

Reaktionsgleichung von HRID 22183
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:12]=[C:11]([O:13][CH2:14][CH3:15])[O:10][C:9](=[O:16])[C:8]=2[C:17]=1[CH3:18])([O-])=O>C(OCC)(=O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[N:12]=[C:11]([O:13][CH2:14][CH3:15])[O:10][C:9](=[O:16])[C:8]=2[C:17]=1[CH3:18]

Komponenten

4

Edukt 1

HCID 152831736-Nitro-5-methyl-2-ethoxy-3,1-benzoxazin-4-one

Produkt 1

HCID 152831746-Amino-5-methyl-2-ethoxy-3,1-benzoxazin-4-oneAusbeute 71 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of 4.0 g (16 mmoles) of 6-nitro-5-methyl-2-ethoxy-3,1-benzoxazin-4-one in 65 mL ethyl acetate was transferred to a Parr bottle. 1.0 g (0.94 mmoles) 10% Pd/C catalyst (obtained from Matheson, Coleman & Bell) was added. The sample was hydrogenated on a Parr shaker at ambient room temperature and 1 atm pressure for 5 hours. The catalyst was removed by filtration through a pad of Celite. The filtrate was concentrated in vacuo to produce a bright yellow solid. There was obtained 2.5 g (71% yield) of 6-amino-5-methyl-2-ethoxy-3,1-benzoxazin-4-one. NMR (DMSO-d6): 1.33(t,3H,J=6.9 Hz), 2.46(s,3H), 4.36(q,2H,J=6.9 Hz), 5.24(bs,2H), 7.05(d,1H,J=8.4 Hz), 7.14(d,1H,J=8.4 Hz). IR(nujol): 1743 cm-1 (lactone carbonyl). MS(m/z): 220(M+).

Aufarbeitung

  1. customwas hydrogenated on a Parr shaker at ambient room temperature
  2. customThe catalyst was removed by filtration through a pad of Celite
  3. concentrationThe filtrate was concentrated in vacuo
  4. customto produce a bright yellow solid

Quellen und Nachweise

ORD-Eintrag
ord-3e8b6797605a414c915acc79bb35d696
Quelldatensatz
uspto-grants-1995_06
Patentnummer
US05428021

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