Benzoyl Peroxide → 4-Bromoethyl-isophthalic acid dimethylester

HRID 2218937Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2218937
[CH3:1][O:2][C:3](=[O:14])[C:4]1C=CC(C)=C(C(O)=O)[CH:5]=1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.[Br:33]N1C(=O)CCC1=O.C[CH2:42][CH2:43][CH2:44][CH2:45][CH3:46].C[CH2:48][O:49][C:50]([CH3:52])=[O:51]>C(Cl)(Cl)(Cl)Cl>[CH3:48][O:49][C:50](=[O:51])[C:52]1[CH:46]=[CH:45][C:44]([CH2:43][CH2:42][Br:33])=[C:4]([C:3]([O:2][CH3:1])=[O:14])[CH:5]=1

Komponenten

6

Edukt 4

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 21226206Ethyl acetate hexaneHCID 229994865-(Methoxycarbonyl)-2-methylbenzoic acid

Produkt 1

HCID 537536654-Bromoethyl-isophthalic acid dimethylester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

A mixture of (4) (0.96 g, 4.61 mmol), dibenzoylperoxide (56 mg, 0.23 mmol) and N-bromosuccinimide (NBS) (0.82 g, 4.61 mmol) in carbon tetrachloride (20 ml) was heated at reflux for 20 hours. After cooling to room temperature and filteration the solvent was evaporated to give a yellow oil. Flash chromatograph: silica, hexane/EtOAc (7:3) afforded the pure compound.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 20 hours
  3. customfilteration the solvent was evaporated
  4. customto give a yellow oil

Quellen und Nachweise

ORD-Eintrag
ord-6f4713bd9ddb44dd955be17255b13fbc
Quelldatensatz
uspto-grants-2008_08
Patentnummer
US07413727B2

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