Water → ((4-Cyclohexylphenoxy)methyl)oxirane

HRID 221948

Reaktionsgleichung

Reaktionsgleichung von HRID 221948
[CH2:1]1[O:3][C@H:2]1[CH2:4]Cl.[CH:6]1([C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.C(=O)([O-])[O-].[Cs+].[Cs+].O>C(#N)C>[CH:6]1([C:12]2[CH:13]=[CH:14][C:15]([O:18][CH2:4][CH:2]3[CH2:1][O:3]3)=[CH:16][CH:17]=2)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 10796Cesium carbonateHCID 143274-CyclohexylphenolHCID 2734062(-)-Epichlorohydrin

Produkt 1

HCID 5743581((4-Cyclohexylphenoxy)methyl)oxirane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

To a mixture of R-epichlorohydrin (9.8 g, 106 mmol) and 4-cyclohexylphenol (3.73 g, 21.2 mmol) in acetonitrile (40 ml) was added cesium carbonate (6.9 g, 21.2 mmol). The mixture was heated at reflux for 3 hours. The reaction mixture was cooled, poured into water (100 mL) and extracted twice with EtOAc. The organic phases were combined and washed with water, brine, dried (Na2SO4), concentrated and dried under high vacuum overnight to give the title compound.

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 3 hours
  3. temperatureThe reaction mixture was cooled
  4. extractionextracted twice with EtOAc
  5. washwashed with water, brine
  6. dry with materialdried (Na2SO4)
  7. concentrationconcentrated
  8. customdried under high vacuum overnight

Quellen und Nachweise

ORD-Eintrag
ord-d3037173a1b8480bbbcf4512227dd842
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08207181B2

Verknüpfte Notizen

Wird geladen…