5-Aminoquinoline → 5-[4-(5-Fluoro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentylamino]quinoline

HRID 2220247Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2220247
FC1C=C(C(C)(C)CC(O)(C(F)(F)F)C=O)C2OCCC=2C=1.NC1C=CC=C2C=1C=CC=N2.[F:34][C:35]1[CH:36]=[C:37]([C:44]([CH3:65])([CH3:64])[CH2:45][C:46]([OH:63])([C:59]([F:62])([F:61])[F:60])[CH:47]=[N:48][C:49]2[CH:58]=[CH:57][CH:56]=[C:55]3[C:50]=2[CH:51]=[CH:52][CH:53]=[N:54]3)[C:38]2[O:42][CH2:41][CH2:40][C:39]=2[CH:43]=1.[BH4-].[Na+]>>[F:34][C:35]1[CH:36]=[C:37]([C:44]([CH3:65])([CH3:64])[CH2:45][C:46]([OH:63])([C:59]([F:60])([F:62])[F:61])[CH2:47][NH:48][C:49]2[CH:58]=[CH:57][CH:56]=[C:55]3[C:50]=2[CH:51]=[CH:52][CH:53]=[N:54]3)[C:38]2[O:42][CH2:41][CH2:40][C:39]=2[CH:43]=1

Komponenten

5

Edukt 4

HCID 119115-AminoquinolineHCID 4311764Sodium borohydrideHCID 441849894-(2,3-Dihydro-5-fluoro-7-benzofuranyl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentanalHCID 68851814HCID 68851814, Verbindung

Produkt 1

HCID 115759705-[4-(5-Fluoro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentylamino]quinoline

Versuchsvorschrift

Analogously to Example 1, 4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentanal is converted with 5-aminoquinoline into 5-[4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentylidenamino]quinoline, which is reduced with sodium borohydride to the product.

Quellen und Nachweise

ORD-Eintrag
ord-6157d2380b7646d48fafc8bf2f1e4af8
Quelldatensatz
uspto-grants-2008_08
Patentnummer
US07417056B2

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