HCID 22291207, Verbindung → tert-Butyl 1,7-diazaspiro[4.4]nonane-7-carboxylate

HRID 2223177Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2223177
C([N:8]1[CH2:23][CH2:22][CH2:21][C:9]21[CH2:13][N:12]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:11][CH2:10]2)C1C=CC=CC=1>CO.[Pd]>[CH2:13]1[C:9]2([CH2:21][CH2:22][CH2:23][NH:8]2)[CH2:10][CH2:11][N:12]1[C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15]

Komponenten

4

Edukt 1

HCID 22291207HCID 22291207, Verbindung

Produkt 1

HCID 22291199tert-Butyl 1,7-diazaspiro[4.4]nonane-7-carboxylateAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of t-butyl 6-benzyl-2,6-diazaspiro[4.4]nonane-2-carboxylate (1.70 g, 5.37 mmol) in methanol (30 mL) was mixed with 10% palladium on carbon (50 mg). The mixture was shaken under a hydrogen atmosphere (50 psi) in a Parr hydrogenation apparatus for 8 h and filtered through Celite. The filtrate was concentrated by rotary evaporation and high vacuum treatment, leaving 1.26 g of viscous, light brown oil (>100%), which was of sufficient purity to be used in the subsequent reaction.

Aufarbeitung

  1. filtrationfiltered through Celite
  2. concentrationThe filtrate was concentrated by rotary evaporation and high vacuum treatment

Quellen und Nachweise

ORD-Eintrag
ord-cd5a9b9706e947a7b3cda5a83686a28e
Quelldatensatz
uspto-grants-2008_05
Patentnummer
US07375110B2

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