Hydrogen Peroxide → 2-tert-Butyl-1-oxo-1lambda~5~-pyridinato

HRID 2225155Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2225155
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH:11]O>CC(O)=O.C(Cl)Cl>[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N+:6]=1[O-:11])([CH3:4])([CH3:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 784Hydrogen PeroxideHCID 1386302-tert-Butylpyridine

Produkt 1

HCID 187150642-tert-Butyl-1-oxo-1lambda~5~-pyridinatoAusbeute 71,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Preparation C3, Step 1: 2-tert-butylpyridine (2.00 g, 14.8 mmol, 1 eq.) was dissolved in HOAc (10 mL) and 30% hydrogen peroxide (1.68 mL, 14.8 mmol, 1 eq.) at room temperature then the reaction was refluxed for 20 hours. The reaction was stripped to obtain an amber oil which was dissolved in methylene chloride (10 mL) then dried over sodium sulfate and stripped to obtain 2-tert-butylpyridine-N-oxide (1.60 g) as an amber oil. Yield=71.5%. LCMS detects (M+H)+=152.09.

Aufarbeitung

  1. customto obtain an amber oil which
  2. dry with materialthen dried over sodium sulfate

Quellen und Nachweise

ORD-Eintrag
ord-4b1dd3f414b84937a21c00a0534e0dc5
Quelldatensatz
uspto-grants-2008_05
Patentnummer
US07378409B2

Notizen zur Reaktion

Wird geladen…