1-Azidomethyl-4-methyl-2-oxabicyclo[2.2.2]octan-3-one → 1-Aminomethyl-4-methyl-2-oxabicyclo[2.2.2]-octan-3-one

HRID 2225490Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2225490
[N:1]([CH2:4][C:5]12[CH2:12][CH2:11][C:8]([CH3:13])([CH2:9][CH2:10]1)[C:7](=[O:14])[O:6]2)=[N+]=[N-].[H][H]>C(O)C.[Pt](=O)=O>[NH2:1][CH2:4][C:5]12[CH2:12][CH2:11][C:8]([CH3:13])([CH2:9][CH2:10]1)[C:7](=[O:14])[O:6]2

Komponenten

5

Edukt 2

HCID 190047971-Azidomethyl-4-methyl-2-oxabicyclo[2.2.2]octan-3-oneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 190047031-Aminomethyl-4-methyl-2-oxabicyclo[2.2.2]-octan-3-oneAusbeute 84,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

0.025 g of platinum dioxide was added to a solution of 0.6 g of 1-azidomethyl-4-methyl-2-oxabicyclo[2.2.2]octan-3-one (Example 29) in 30 ml of ethanol. The resultant solution was reacted for 14 hours under 3.5 atom hydrogen gas. After reaction, the catalyst was filtered out, and the solvent was removed in vacuo from the filtrate. As a result, 0.44 g of 1-aminomethyl-4-methyl-2-oxabicyclo[2.2.2]-octan-3-one was obtained as a pale yellow oil, which had the following physiochemical properties:

Aufarbeitung

  1. customAfter reaction
  2. filtrationthe catalyst was filtered out
  3. customthe solvent was removed in vacuo from the filtrate

Quellen und Nachweise

ORD-Eintrag
ord-651ea7f3fdfc4619b4c7a8a05981a4ef
Quelldatensatz
uspto-grants-1994_09
Patentnummer
US05344845

Notizen zur Reaktion

Wird geladen…