Sodium Carbonate → HCID 85650986, Verbindung
Reaktionsgleichung
O=[C:2]([CH3:8])[CH2:3][CH2:4][CH2:5][C:6]#[N:7].Cl.[NH2:10][OH:11].C(=O)([O-])[O-].[Na+].[Na+]>>[N:10](=[C:2]([CH3:8])[CH2:3][CH2:4][CH2:5][C:6]#[N:7])[OH:11]Komponenten
4
Versuchsvorschrift
Chem. Ber. 1966, 3387 to 3389 discloses the preparation of 1,5-diaminohexane from 5-oxocapronitrile. In this process, 1,5-diaminohexane is only obtained via the oxime intermediate by first reacting 5-oxocapronitrile with hydroxylamine hydrochloride in the presence of anhydrous sodium carbonate to give 5-oximinocapronitrile, which is subsequently reacted with lithium aluminum hydride to give the diamine; the overall yield is 42%. According to the authors, direct reductive amination of 5-oxocapronitrile gives the cyclization product, 2-methylpiperidine.
Quellen und Nachweise
- ORD-Eintrag
- ord-1f66391739bf45c79c3eea5a1522f43d
- Quelldatensatz
- uspto-grants-1994_09
- Patentnummer
- US05344983
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