Sodium Cyanide → 5-Bromopyrimidine-2-carbonitrile
Reaktionsgleichung
[C-:1]#[N:2].[Na+].[Br:4][C:5]1[CH:6]=[N:7][C:8](Cl)=[N:9][CH:10]=1>CN(C)C=O.O>[Br:4][C:5]1[CH:6]=[N:7][C:8]([C:1]#[N:2])=[N:9][CH:10]=1Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
Sodium cyanide (2.30 g, 46.6 mmol) was dissolved in dimethylformamide (60 ml) and treated with 5-bromo-2-chloropyrimidine (6.0 g, 31.1 mmol). The resulting mixture was stirred at room temperature for 18 hours, diluted with water and extracted with dichloromethane. The dichloromethane extracts were combined, washed with water, dried (magnesium sulphate), filtered and concentrated in vacuo. The crude product was purified by column chromatography eluting with a mixture of ethyl acetate:hexane (1:4) to afford the title compound (D38).
Aufarbeitung
- extractionextracted with dichloromethane
- washwashed with water
- dry with materialdried (magnesium sulphate)
- filtrationfiltered
- concentrationconcentrated in vacuo
- customThe crude product was purified by column chromatography
- washeluting with a mixture of ethyl acetate:hexane (1:4)
Quellen und Nachweise
- ORD-Eintrag
- ord-a84687f9b7854a1796316c632dea7ae1
- Quelldatensatz
- uspto-grants-2012_06
- Patentnummer
- US08207331B2
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