Ethanol → Aminolevulinic acid phosphate

HRID 222816

Reaktionsgleichung

Reaktionsgleichung von HRID 222816
Cl.[NH2:2][CH2:3][C:4](=[O:10])[CH2:5][CH2:6][C:7]([OH:9])=[O:8].[P:11](=[O:15])([OH:14])([OH:13])[OH:12].C(N(CC)CC)C.C(O)C>O>[P:11]([OH:15])([OH:14])([OH:13])=[O:12].[NH2:2][CH2:3][C:4](=[O:10])[CH2:5][CH2:6][C:7]([OH:9])=[O:8]

Komponenten

6

Edukt 4

HCID 702EthanolHCID 1004Phosphoric AcidHCID 8471TriethylamineHCID 123608Aminolevulinic Acid Hydrochloride

Produkt 1

HCID 24737828Aminolevulinic acid phosphate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A 40 g (239 mmol) portion of δ-aminolevulinic acid hydrochloride and 18 ml (263 mmol) of 85% phosphoric acid were dissolved in 120 ml of purified water, and 25.4 g mmol) of triethylamine was added dropwise thereto while stirring on an ice bath. After completion of the dropwise addition and subsequent stirring at room temperature for 10 minutes, 1.6 L of ethanol was added thereto and stirred. The thus precipitated precipitate was recovered by suction filtration and dried at room temperature for 16 hours under a reduced pressure. A 51 g (224 mmol) portion of δ-aminolevulinic acid phosphate was obtained at a yield of 93 mol %.

Aufarbeitung

  1. additionAfter completion of the dropwise addition
  2. stirringsubsequent stirring at room temperature for 10 minutes
  3. stirringstirred
  4. filtrationThe thus precipitated precipitate was recovered by suction filtration
  5. customdried at room temperature for 16 hours under a reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-03aff9b54ec140d99b2fc56d12619989
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08207376B2

Verknüpfte Notizen

Wird geladen…