3,3-Dimethyl-1-[2-benzylperhydropyridazinyl]pentane-1,2-dione → 3,3-Dimethyl-1-perhydropyridazinylpentane-1,2-dione

HRID 2228456

Reaktionsgleichung

Reaktionsgleichung von HRID 2228456
[CH3:1][C:2]([CH3:22])([CH2:20][CH3:21])[C:3](=[O:19])[C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][NH:8][N:7]1CC1C=CC=CC=1)=[O:5]>CCO.[Pd]>[CH3:1][C:2]([CH3:22])([CH2:20][CH3:21])[C:3](=[O:19])[C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][NH:8][NH:7]1)=[O:5]

Komponenten

4

Edukt 1

HCID 184700773,3-Dimethyl-1-[2-benzylperhydropyridazinyl]pentane-1,2-dione

Produkt 1

HCID 694178043,3-Dimethyl-1-perhydropyridazinylpentane-1,2-dione

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

1 g 10% Pd/C was added to a solution of 3,3-dimethyl-1-[2-benzylperhydropyridazinyl]pentane-1,2-dione (7.0 g, 20.2 mmol) in 70 ml EtOH. The mixture was under hydrogenation at room pressure (1 atm) overnight. The product was obtained as white solid after filtering Pd catalyst and concentration (3.8 g, 89%). 1H NMR (CDCl3, 400 MHz) δ 0.88 (t, 3H, J=7.0); 1.19 (s, 6H); 1.65 (m, 4H); 1.79 (m, 2H); 2.85 (m, 2H); 3.42 (m, 1H); 3.56 (m, 1H).

Aufarbeitung

  1. customwas under hydrogenation at room pressure (1 atm) overnight
  2. customThe product was obtained as white solid
  3. filtrationafter filtering
  4. concentrationPd catalyst and concentration (3.8 g, 89%)

Quellen und Nachweise

ORD-Eintrag
ord-d65e097f93674abca697f319e99165bb
Quelldatensatz
uspto-grants-2002_07
Patentnummer
US06417189B1

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