Hydrochloric Acid → (S)-3-[(2S,3R,4R,5S)-2,3,4,6-tetrahydroxy-5-(L-leucyl)aminohexanoyl]amino-3-phenylpropionic acid hydrochloride

HRID 2230398Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2230398
[OH:1][C@@H:2]([C@H:17]([OH:32])[C@H:18]([OH:31])[C@@H:19]([NH:22][C:23](=[O:30])[C@H:24]([CH2:26][CH:27]([CH3:29])[CH3:28])[NH2:25])[CH2:20][OH:21])[C:3]([NH:5][C@H:6]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:7][C:8]([OH:10])=[O:9])=[O:4].[ClH:33]>O>[ClH:33].[OH:1][C@@H:2]([C@H:17]([OH:32])[C@H:18]([OH:31])[C@@H:19]([NH:22][C:23](=[O:30])[C@H:24]([CH2:26][CH:27]([CH3:28])[CH3:29])[NH2:25])[CH2:20][OH:21])[C:3]([NH:5][C@H:6]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:7][C:8]([OH:10])=[O:9])=[O:4]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 10456696(S)-3-[(2S,3R,4R,5S)-2,3,4,6-tetrahydroxy-5-(L-leucyl)aminohexanoyl]amino-3-phenylpropionic acid2×

Produkt 1

HCID 69823761(S)-3-[(2S,3R,4R,5S)-2,3,4,6-tetrahydroxy-5-(L-leucyl)aminohexanoyl]amino-3-phenylpropionic acid hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of (S)-3-[(2S,3R,4R,5S)-2,3,4,6-tetrahydroxy-5-(L-leucyl)aminohexanoyl]amino-3-phenylpropionic acid (Compound 3) (2.00 g) in water (50 ml) was added 1N hydrochloric acid (4.83 ml). After the mixture was filtrated through membrane filter, the filtrate was concentrated under reduced pressure. Recrystallization from methanol-diethylether provided the title compound (1.84 g).

Aufarbeitung

  1. filtrationAfter the mixture was filtrated through membrane
  2. filtrationfilter
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customRecrystallization from methanol-diethylether

Quellen und Nachweise

ORD-Eintrag
ord-c368a0fa8157497aa5b056007261026c
Quelldatensatz
uspto-grants-2002_07
Patentnummer
US06423869B1

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