Hydrochloric Acid → 2-Methoxy-5-(5-methylsulfonyltetrazol-1-yl)benzoic acid

HRID 2230630Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2230630
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]([S:18]([CH3:21])(=[O:20])=[O:19])=[N:16][N:15]=[N:14]2)=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].CO.[OH-].[Na+].Cl>ClCCl.O>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]([S:18]([CH3:21])(=[O:20])=[O:19])=[N:16][N:15]=[N:14]2)=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 18464688methyl 2-methoxy-5-(5-methylsulfonyl-1H-tetrazol-1-yl)benzoate

Produkt 1

HCID 184644382-Methoxy-5-(5-methylsulfonyltetrazol-1-yl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Combine methyl 2-methoxy-5-(5-methylsulfonyl-1H-tetrazol-1-yl)benzoate (5 mmol), methanol (10 mL), and a 1 M aqueous sodium hydroxide solution (6 mL, 6.0 mmol). After 18 hours, evaporate in vacuo to give a residue. Combine the residue, water (5 mL) and acidify by dropwise addition of a 1 M aqueous hydrochloric acid solution (6.5 mL). Evaporate in vacuo to give a residue. Combine the residue and dichloromethane and stir. Decant and add dichloromethane and stir. Decant and combine with the first decantate. Dry over Na2SO4, filter, and concentrate in vacuo to give the title compound.

Aufarbeitung

  1. customevaporate in vacuo
  2. customto give a residue
  3. customEvaporate in vacuo
  4. customto give a residue
  5. customDecant
  6. additionadd dichloromethane
  7. stirringstir
  8. customDecant
  9. dry with materialDry over Na2SO4
  10. filtrationfilter
  11. concentrationconcentrate in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ccd1973a824242b4abd9090f72f3df82
Quelldatensatz
uspto-grants-2002_07
Patentnummer
US06423704B1

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