Hydrochloric Acid → Hydrochloric Acid

HRID 223102

Reaktionsgleichung

Reaktionsgleichung von HRID 223102
C([O:5][C:6]([C@@H:8]([N:10]1[C@H:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C@H:12]([N:20]=[N+]=[N-])[C:11]1=[O:23])[CH3:9])=[O:7])(C)(C)C.[ClH:24]>[Pd].C(O)C>[ClH:24].[NH2:20][C@H:12]([C:11]([NH:10][C@H:8]([C:6]([OH:7])=[O:5])[CH3:9])=[O:23])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Komponenten

6

Edukt 2

HCID 313Hydrochloric AcidHCID 130352141-(1(S)-t-butoxycarbonylethyl)-3(S)-azido-4(R)-phenylazetidin-2-one

Produkt 2

HCID 313Hydrochloric AcidHCID 5488196L-Phenylalanyl-L-alanine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

After 1-(1(S)-t-butoxycarbonylethyl)-3(S)-azido-4(R)-phenylazetidin-2-one (200 mg., 0.63 mmol) was hydrogenated in 50 ml. of ethanol under ambient pressure at room temperature for 4 hours, using a 10% Pd-C (200 mg.) as a catalyst, 1 normal (1 N) hydrochloric acid (0.76 ml.) was added thereto. Then, the hydrogenation under ambient pressure was continued further for 15 hours at 50° C. to give quantitatively hydrochloride of t-butyl ester of L-phenylalanyl-L-alanine.

Quellen und Nachweise

ORD-Eintrag
ord-09185ea036d2460c90ab07f7f309f84f
Quelldatensatz
uspto-grants-1982_10
Patentnummer
US04352752

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