Hydrochloric Acid → 2-Hydroxybenzo(b)thiophene-3-carboxamide

Reaktionsgleichung

C(N[C:5]1[S:9][C:8]2[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=2[C:6]=1[C:14]#[N:15])(=O)C.C([OH:18])C.Cl.[OH2:20]>>[OH:20][C:5]1[S:9][C:8]2[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=2[C:6]=1[C:14]([NH2:15])=[O:18]

Komponenten

Edukt 4

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 962Water2×

HCID 21286564N-(3-Cyano-1-benzothiophen-2-yl)acetamide

Produkt 1

HCID 142579342-Hydroxybenzo(b)thiophene-3-carboxamide

Versuchsvorschrift

A mixture of 2-acetamido-3-cyanobenzo(b)thiophene (2.2 g, 0.01 m), ethanol (25 ml), water (15 ml) and concentrated hydrochloric acid (25 ml) is heated under reflux for 12 hours. The reaction mixture is diluted with water, aged and filtered to yield 2-hydroxybenzo(b)thiophene-3-carboxamide.