4-Toluenesulfonyl chloride → HCID 20523222, Verbindung

HRID 223147Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 223147
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:15]=[CH:16][CH:17]=1)[CH:6]([NH:8][CH2:9][CH:10]([O:13][CH3:14])[O:11][CH3:12])[CH3:7].[S:18](Cl)([C:21]1[CH:27]=[CH:26][C:24]([CH3:25])=[CH:23][CH:22]=1)(=[O:20])=[O:19]>N1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:15]=[CH:16][CH:17]=1)[CH:6]([N:8]([CH2:9][CH:10]([O:11][CH3:12])[O:13][CH3:14])[S:18]([C:21]1[CH:27]=[CH:26][C:24]([CH3:25])=[CH:23][CH:22]=1)(=[O:20])=[O:19])[CH3:7]

Komponenten

4

Edukt 2

HCID 73974-Toluenesulfonyl chlorideHCID 20523216HCID 20523216, Verbindung

Produkt 1

HCID 20523222HCID 20523222, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel2×

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

A mixture of 23.9 g. (0.1 mole) of 3-methoxy-α-methyl-N-(2,2-dimethoxyethyl)benzylamine in 100 ml. of dry pyridine is stirred, cooled and treated with a solution of 20.2 g. (0.107 mole) of tosyl chloride in 100 ml. of dry pyridine. The mixture is stirred at 25° C. for three days, poured into 800 ml. of water and extracted with ether. The combined ether extracts are washed with dilute hydrochloric acid and then with water, dried, filtered and evaporated to yield 3-methoxy-α-methyl-N-(2,2-dimethoxyethyl)-N-tosyl-benzylamine.

Aufarbeitung

  1. additionA mixture of 23.9 g
  2. temperaturecooled
  3. additiontreated with a solution of 20.2 g
  4. additionpoured into 800 ml
  5. extractionof water and extracted with ether
  6. washThe combined ether extracts are washed with dilute hydrochloric acid
  7. dry with materialwith water, dried
  8. filtrationfiltered
  9. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-dc1b35ceb41247bd9bac1d4427577103
Quelldatensatz
uspto-grants-1982_10
Patentnummer
US04352809

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