Hydrogen Bromide → HCID 135574541, Verbindung

HRID 2231506Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2231506
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13]C)[CH:9]=[N:8][CH:7]=[CH:6]2.[BrH:15]>C(O)(=O)C>[OH2:2].[BrH:15].[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[OH:13])[CH:9]=[N:8][CH:7]=[CH:6]2

Komponenten

4

Edukt 2

HCID 260Hydrogen BromideHCID 1775786,7-Dimethoxyisoquinoline

Produkt 1

HCID 135574541HCID 135574541, VerbindungAusbeute 88,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

1.9 g (10 mmol) of 6,7-dimethoxyisoquinoline was dissolved in a mixture of 15 ml of acetic acid and 15 ml of 40% hydrobromic acid, and the solution was stirred under reflux for 24 hours under a nitrogen atmosphere. The reaction solution was concentrated under reduced pressure. The residue was recrystallized from a 1N hydrobromic acid aqueous solution to obtain 2.3 g (yield: 88.4%) of the above identified compound. The melting point, infrared spectrum and NMR spectrum agreed to those of the compound of Example 10.

Aufarbeitung

  1. temperatureunder reflux for 24 hours under a nitrogen atmosphere
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. customThe residue was recrystallized from a 1N hydrobromic acid aqueous solution
  4. customto obtain 2.3 g (yield: 88.4%) of the

Quellen und Nachweise

ORD-Eintrag
ord-5fb7dc371c5f4312ba3b7af1c157c608
Quelldatensatz
uspto-grants-1988_11
Patentnummer
US04782155

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