Benzylamine → 2-Amino-3-cyano-4-benzylaminoquinoline

HRID 2233276Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2233276
[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH2:15]([NH2:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>O>[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:22][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Komponenten

4

Edukt 2

HCID 7504BenzylamineHCID 114811212-Amino-3-cyano4-chloroquinoline

Produkt 1

HCID 112888282-Amino-3-cyano-4-benzylaminoquinoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

5 g of 2-amino-3-cyano-4-chloroquinoline and 11 ml of benzylamine are heated under stirring at 130° C. The reaction mixture is poured onto 50 ml of water, the resulting precipitate is filtered off, washed with 50 ml of water. The pale-yellow precipitate is recrystallized from 25 ml of dimethylformamide to obtain 5.2 g of the title compound. Mp.: 206° C.

Aufarbeitung

  1. filtrationthe resulting precipitate is filtered off
  2. washwashed with 50 ml of water
  3. customThe pale-yellow precipitate is recrystallized from 25 ml of dimethylformamide

Quellen und Nachweise

ORD-Eintrag
ord-96d984991a4e4e2e84d59c74b9d873c2
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07709489B2

Notizen zur Reaktion

Wird geladen…